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KMID : 0378019670100070065
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New Medical Journal
1967 Volume.10 No. 7 p.65 ~ p.70
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The Effect of Cysteine Against Total Body X-Irradiaionon the Blood Protein
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Abstract
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This study was planned to see whether the Panax Ginseng has any influence upon the stress mechanism in rats exposed to cold and heat environment.
Dividing 120 male albino rats with weights ranging from 150 to 200 gram, into sodium chloride group (which received subcutaneous saline injection) and ginseng extract group (which received subcutaneous injection of ginseng extract) acclimated at least for 13 days to three condition; cold, optimal condition, or heat (10´C, 20´C, or 30´C), experiments were carried out as follows:
For consecutive days the ginseng extract group and sodium chloride group as control group received each day 0.5 ml per 100 gram body weight of ginseng extract and physiological saline, respectively. At the same time. rats received ginseng extract or saline acclimated to cold or heat. On the final day after begining of ginseng extract or physiological saline administration, the adrenal ascorbic acid content and the eosinophil count were measured.
To prepare ginseng extract, 300 gram of Korean Panax Ginseng was extracted with 95% ethyl alcohol in a boiling water bath for about 300 hours. This procedure yielded 50 gram of dark brown substance, from which a "ginseng extract´ was prepared, dissolved 4 mg of the substance in 1 ml of physiological saline.
Adrenal ascorbic acid content and eosinophil count served as an indicator of reaction to stress. The ascorbic acid content has been studied colorimeterically with Toyo densitometer (Type 1) utilizing the reduction of 2, 6-eichlorophenol-indophenol sodium, and the eosinophil count studied using HinkeIman´s solution, respectively.
1) Ginseng extract has no influence upon the adrenal ascorbic acid content and the eosinophil count of rats unier optimal condition, 200C.
2) The adrenal ascorbic acid content and the eosinophil count of the sodium chloride group whicli exposed to cold or heat (10´C or 30´C) decreased significantly over that of the sodium chloride group under optimal condition, 20´C.
3) Ginseng extract greatly delays the decrease of the adrenal ascorbic acid content and the^eosinophil count of rats to exposure to cold or heat (10C or 30C).
It may be inferred that ginseng extract has no influence upon optimal condition (20´C) and tL-it ginseng extract greatly delays the decrease of adrenal ascorbic acid content and the eosinophil count of rats exposed to cold or heat (10´C or 30´C), provided that the ginseng extract is given consecutively.
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